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Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
Published on: October 25, 2015
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A Systematic Review and Meta-Analysis of Physiologic Variables in Sheep Fetuses
Ayssa Teles Abrao Trad1, Megan E Branda2,3, Sarah W Felisbino4
11Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota.
Comparative Medicine
|August 28, 2024
Summary
This study systematically reviewed fetal sheep data, establishing reference values for hemodynamics, blood gases, and acid-base status. Findings highlight significant heterogeneity in existing literature, necessitating careful interpretation of fetal physiology research.
Area of Science:
- Perinatal Medicine
- Fetal Physiology Research
- Comparative Animal Models
Background:
- The fetal sheep model is crucial for advancing fetal therapy research.
- Existing literature shows considerable variability in reported normal physiological values for fetal sheep.
- This inconsistency complicates the interpretation of research findings and the development of clinical interventions.
Conclusions:
- Significant heterogeneity exists within the published literature on fetal sheep physiology.
- The study provides updated reference values for key hemodynamic and blood gas parameters.
- These findings aid in standardizing research and improving the reliability of the fetal sheep model in translational studies.
