Histologic improvement predicts endoscopic remission in patients with ulcerative colitis
Ji Eun Kim1, Minjee Kim1, Min-Ji Kim2
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Scientific Reports
|August 28, 2024
Summary
Histologic improvement predicts endoscopic remission in ulcerative colitis (UC) patients with low endoscopic scores. Achieving histologic improvement reduces the likelihood of clinical relapse in UC.
Area of Science:
- Gastroenterology
- Inflammatory Bowel Disease Research
- Clinical Pathology
Background:
- Histologic improvement is a potential prognosticator for endoscopic remission in ulcerative colitis (UC).
- Limited research exists on the predictive value of histological activity for endoscopic remission in UC patients with low endoscopic scores.
Purpose of the Study:
- To evaluate if histological activity predicts endoscopic remission in UC patients with Mayo endoscopic subscores (MES) of 0 or 1.
- To compare clinical outcomes between patients with histologic improvement and those with active histologic disease.
Main Methods:
- Retrospective analysis of 492 UC patients with MES 0 or 1 between January 2018 and December 2020.
- Categorization into two cohorts: histologic improvement and active histologic disease.
- Assessment of endoscopic activity during follow-up, with primary outcome as endoscopic remission based on histologic activity.
Main Results:
- Patients with histologic improvement were more likely to achieve endoscopic remission compared to those with active histology.
- The group with active histology had a higher likelihood of clinical relapse.
- Endoscopic activity was assessed in 435 patients during initial follow-up and 146 during subsequent follow-up.
Conclusions:
- Histologic improvement is a significant predictor of endoscopic remission in UC patients with low endoscopic scores (MES 0-1).
- Maintaining histologic improvement is associated with a lower risk of clinical relapse in UC.
- Histological assessment is valuable for predicting therapeutic response and clinical outcomes in UC management.
Keywords:
Endoscopic healingEndoscopic remissionHistologic activityHistologic remissionMucosal healingUlcerative colitisMore Related Videos
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
31.7K
09:42Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
18.6K
Related Concept Videos
01:21Inflammatory Bowel Disease V: Surgical Management
133
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
133
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
328
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
328
01:29Drugs for Treatment of Ulcerative Colitis in IBD
130
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
130
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
159
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
159
01:30Inflammatory Bowel Disease II: Crohn's Disease
205
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
205
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
100
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
100