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  11. The Soluble St2 Level Predicts Risk Of Atrial Fibrillation Recurrences In Long-term Period After Radiofrequency Ablation

The soluble ST2 level predicts risk of atrial fibrillation recurrences in long-term period after radiofrequency ablation

Tatiana P Gizatulina1, Aleksandra V Mamarina2, Leysan U Martyanova2

  • 1Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences, 111 Melnikaite Street, Tyumen, 625026, Russian Federation. gizatulinatp@infarkta.net.

BMC Cardiovascular Disorders
|August 28, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Serum soluble ST2 (sST2) levels ≥ 36 ng/ml predict atrial fibrillation recurrence after radiofrequency catheter ablation. This finding aids in long-term risk stratification for patients undergoing AF ablation.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Electrophysiology

Background:

  • Atrial fibrillation (AF) recurrence after radiofrequency catheter ablation (RFA) remains a clinical challenge.
  • Predictive markers for long-term AF recurrence are crucial for patient management.
  • Soluble ST2 (sST2) and GDF-15 are investigated as potential biomarkers.

Purpose of the Study:

  • To evaluate serum sST2 and GDF-15 levels as predictors of long-term AF recurrence post-RFA.
  • To identify independent predictors of AF recurrence after primary RFA.

Main Methods:

  • Prospective follow-up of 131 patients for 18 months post-RFA.
  • Measurement of pre-RFA serum sST2 and GDF-15 levels using ELISA.
  • Assessment of AF recurrence (AFr) via ECG and Holter monitoring.
Keywords:
Atrial fibrillationBiomarkersLeft atrial fibrosisRadiofrequency ablation

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Main Results:

  • 47 patients (35.9%) experienced AFr at 18 months.
  • Higher sST2 levels (≥ 36 ng/ml) were associated with increased AFr risk.
  • Multivariate analysis identified sST2 ≥ 36 ng/ml (HR=3.8) and LAAFV < 54 cm/sec (HR=1.96) as independent predictors.

Conclusions:

  • Serum sST2 level ≥ 36 ng/ml is a significant predictor of long-term AF recurrence after RFA.
  • sST2 may serve as a valuable biomarker for risk stratification in AF patients post-ablation.
sST2