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Severe bronchiectasis is associated with increased carotid intima-media thickness
Wang Chun Kwok1, Kui Kai Lau1,2, Kay Cheong Teo1
1Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Pokfulam, Hong Kong SAR, China.
BMC Cardiovascular Disorders
|August 28, 2024
Summary
Severe bronchiectasis is linked to increased subclinical atherosclerosis, measured by carotid intima-media thickness (CIMT). Mild-to-moderate bronchiectasis showed no significant difference in CIMT compared to controls.
Area of Science:
- Cardiology
- Pulmonology
- Medical Imaging
Background:
- Bronchiectasis is associated with cardiovascular disease.
- Limited evidence exists on bronchiectasis and subclinical atherosclerosis, specifically carotid intima-media thickness (CIMT).
Purpose of the Study:
- To compare CIMT in patients with and without bronchiectasis.
- To assess the association between bronchiectasis severity (using FACED score) and CIMT.
Main Methods:
- Prospective study conducted at a Hong Kong hospital.
- Recruited 155 Chinese patients with non-cystic fibrosis bronchiectasis and 512 controls.
- Measured CIMT and analyzed data using multivariate linear regression.
Main Results:
- Mean CIMT was 0.58±0.10 mm (controls), 0.63±0.11 mm (mild-to-moderate bronchiectasis), and 0.66±0.08 mm (severe bronchiectasis).
- No significant CIMT difference between mild-to-moderate bronchiectasis patients and controls.
- Significantly increased CIMT in severe bronchiectasis patients compared to controls, even without prior cardiovascular disease or risk factors.
Conclusions:
- Subclinical atherosclerosis, indicated by increased CIMT, is more prevalent in patients with severe bronchiectasis.
- Mild-to-moderate bronchiectasis did not show a significant association with increased CIMT.
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