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Related Experiment Videos

External radiotherapy in thyroid cancers.

M Tubiana, E Haddad, M Schlumberger

    Cancer
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    External beam radiotherapy (RT) is effective for differentiated thyroid cancer after incomplete surgery, significantly reducing local recurrence. Combining RT with radioiodine aids metastasis detection and is well-tolerated.

    Area of Science:

    • Oncology
    • Radiotherapy
    • Thyroid Cancer Research

    Background:

    • Surgery is the primary treatment for thyroid cancer.
    • Radiotherapy (RT) plays a crucial role in specific patient subsets, particularly after incomplete surgical excision.
    • External-beam RT is indicated when neoplastic tissue remains post-surgery, especially involving critical structures like the larynx, trachea, esophagus, or mediastinum.

    Purpose of the Study:

    • To evaluate the efficacy of external-beam radiotherapy in managing differentiated thyroid cancer.
    • To assess the impact of RT on local recurrence rates and survival following incomplete surgical resection.
    • To compare the effectiveness of external RT with radioiodine and explore combined treatment modalities.

    Main Methods:

    • Retrospective analysis of 97 patients with differentiated thyroid cancer treated with external-beam RT after incomplete surgery.

    Related Experiment Videos

  • Dosimetric evaluation (≥50 Gy) of RT in residual neoplastic tissue.
  • Long-term survival and relapse-free survival rates were analyzed.
  • Serum thyroglobulin and calcitonin levels were used for monitoring treatment effects.

    • Main Results:

    • External-beam RT after incomplete surgery resulted in a 15-year survival rate of 57% and a 25-year survival rate of approximately 40%.
    • Adequate RT doses (≥50 Gy) to residual tumor significantly lowered the 15-year actuarial probability of local recurrence to 11% compared to 23% with surgery alone.
    • Radioiodine showed lower local control but aids in detecting distant metastases; combination therapy is well-tolerated.
    • External RT demonstrated effectiveness in medullary carcinoma, with calcitonin monitoring aiding treatment assessment.

    Conclusions:

    • External-beam radiotherapy is an effective treatment for differentiated thyroid cancer following incomplete surgery, significantly reducing local recurrence rates.
    • Combined external RT and radioiodine therapy is indicated for improved metastasis detection and is well-tolerated.
    • While RT offers limited success in inoperable thyroid cancers and undifferentiated types, it remains a valuable tool in specific oncological scenarios.