Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biologic basis for altered fractionation schemes.

H R Withers

    Cancer
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Radiotherapy fractionation is not one-size-fits-all. Individualizing radiation doses and treatment times can improve therapeutic gains for various tumors and tissues, moving beyond standard fractionation schedules.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Time factor and treatment strategies in subclinical disease.

    International journal of radiation biology·2003
    Same author

    Endothelial cells and radiation gastrointestinal syndrome.

    Science (New York, N.Y.)·2001
    Same author

    Molecular pathways that modify tumor radiation response.

    American journal of clinical oncology·2001
    Same author

    Basic principles and reasonable speculations in intravascular brachytherapy.

    Cardiovascular radiation medicine·2001
    Same author

    Biological aspects of conformal therapy.

    Acta oncologica (Stockholm, Sweden)·2000
    Same author

    Transmutability of dose and time. Commentary on the first report of RTOG 90003 (K. K. FU et al.)

    International journal of radiation oncology, biology, physics·2000

    Area of Science:

    • Radiation Oncology
    • Medical Physics
    • Cancer Therapeutics

    Background:

    • Conventional radiotherapy fractionation is not universally optimal.
    • Fractionation impacts normal tissues and tumors differently based on their response times.
    • Current standard fractionation may not maximize therapeutic ratios.

    Purpose of the Study:

    • To evaluate the potential for improved therapeutic gains by modifying dose per fraction and overall treatment time in radiotherapy.
    • To explore individualized fractionation regimens based on tissue-specific regeneration and tumor kinetics.
    • To advocate for a research focus on personalized radiotherapy schedules.

    Main Methods:

    • Review of radiobiological principles concerning dose fractionation and tissue response.

    Related Experiment Videos

  • Analysis of the impact of overall treatment time on radiotherapy outcomes.
  • Discussion of the challenges in prospectively quantifying tumor and tissue kinetics for treatment individualization.

    • Main Results:

    • Reducing fractional doses below 1.8-2 Gy may enhance sparing of slowly responding normal tissues.
    • Varying onset of regeneration necessitates non-uniform overall treatment durations for different sites and tumor types.
    • Individualized fractionation requires prospective identification and quantification of growth kinetics and dose-response characteristics.

    Conclusions:

    • Curative radiotherapy should generally be delivered in the shortest possible overall time with the smallest practical dose per fraction.
    • While 2 Gy/fraction, 5 times/week is a common standard, it may not be optimal for all patients.
    • Greater individualization of radiotherapy fractionation regimens should be a key research objective.