Related Experiment Video

Updated: Jun 14, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Circular RNA in Cardiovascular Diseases: Biogenesis, Function and Application

Shuai Mei1,2, Xiaozhu Ma1,2, Li Zhou1,2

  • 1Division of Cardiology, Departments of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Ave., Wuhan 430030, China.

Biomolecules
|August 29, 2024
PubMed

Insights

Circular RNAs (circRNAs) are emerging as key players in cardiovascular diseases. This review explores their role in disease mechanisms and potential as biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a major global health concern.
  • Circular RNAs (circRNAs), a class of non-coding RNAs, are increasingly implicated in CVD pathophysiology.
  • Aberrant circRNA expression affects cellular processes vital to cardiovascular health.

Purpose of the Study:

  • To review the properties, biogenesis, and mechanisms of circRNAs in cardiovascular disease.
  • To explore the potential of circRNAs as diagnostic and prognostic biomarkers for CVD.
  • To discuss circRNAs as potential targets for novel cardiovascular drug development.

Main Methods:

  • Comprehensive literature review of circRNAs in cardiovascular disease.
  • Analysis of circRNA functions including microRNA sponging, protein scaffolding, and translation.
  • Examination of circRNA involvement in cardiovascular cellular processes like metabolism and cell death.

Main Results:

  • CircRNAs exhibit diverse functional roles in cardiovascular regulation.
  • Dysregulated circRNA expression is linked to various cardiovascular pathophysiological changes.
  • Unique properties of circRNAs suggest diagnostic and therapeutic potential.

Conclusions:

  • CircRNAs play significant roles in cardiovascular disease development and progression.
  • CircRNAs offer promising avenues for cardiovascular disease diagnosis and treatment.
  • Further research into circRNAs could revolutionize cardiovascular medicine.

Keywords:
biogenesiscardiovascular diseasecircular RNAclinical applicationsdegradation

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