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The Role of Inositols in Endocrine and Neuroendocrine Tumors

Marilda Mormando1, Giulia Puliani1, Marta Bianchini1

  • 1Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.

Biomolecules
|August 29, 2024
PubMed

Insights

Inositols show promise in cancer treatment by regulating key cellular pathways. This review explores their potential as an adjuvant therapy for endocrine and neuroendocrine tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Inositols are involved in cancer prevention and treatment across various neoplasms.
  • Their mechanisms include regulating survival, proliferation, immunity, and oxidative stress pathways.
  • Dysregulation of these pathways is observed in endocrine and neuroendocrine tumors.

Purpose of the Study:

  • To review the molecular mechanisms of inositols in endocrine and neuroendocrine tumors.
  • To evaluate the potential of inositol supplementation as an adjuvant therapy.

Main Methods:

  • Literature review of molecular mechanisms.
  • Analysis of inositol's role in endocrine and neuroendocrine tumor pathways.

Main Results:

  • Inositols modulate pathways crucial to cancer development and progression.
  • Evidence suggests a potential role in endocrine and neuroendocrine tumor contexts.

Conclusions:

  • Inositols possess molecular mechanisms relevant to endocrine and neuroendocrine tumors.
  • Further research is warranted to establish inositol supplementation as an effective adjuvant therapy.
Keywords:
endocrine cancerinositol hexakisphosphateinositolsmyo-inositolsneuroendocrine neoplasmsthyroid cancer

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