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Abnormal Dynamic Reconstruction of Overlapping Communities in Schizophrenia Patients
Yuxiang Guo1, Xubin Wu2, Yumeng Sun2
1School of Software, Taiyuan University of Technology, No.209, University Street, Jinzhong 030600, China.
Schizophrenia patients exhibit altered brain network organization, with decreased stability and activity in dynamic overlapping communities. These changes may reflect impaired information processing in the brain.
Area of Science:
- Neuroscience
- Psychiatry
- Computational Biology
Background:
- Schizophrenia (SZ) is a complex psychiatric disorder characterized by disruptions in brain function.
- Understanding the dynamic nature of brain networks is crucial for elucidating SZ pathophysiology.
Purpose of the Study:
- To investigate alterations in dynamic overlapping brain communities in schizophrenia patients.
- To identify specific patterns of network restructuring associated with SZ.
Main Methods:
- Resting-state functional MRI (rs-fMRI) data from 43 SZ patients and 49 normal controls (NC).
- Dynamic functional connectivity analysis and Jackknife Correlation to build dynamic brain network models.
- Dynamic overlapping community detection to assess structural stability, node functional diversity, and community activity levels.
Main Results:
- Schizophrenia patients showed reduced structural stability of brain communities.
- Decreased functional diversity of overlapping nodes was observed in SZ patients.
- Significantly lower activity levels in overlapping communities were found in SZ patients compared to NC.
Conclusions:
- Brain functional network organization is disrupted in schizophrenia.
- The activity of the brain network for information processing and transmission is weakened in SZ patients.
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