Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic analysis of oesophageal carcinoma (EC) identifies recurrent mutations in histone methyltransferases as a distinctive subset.

Oncogene·2026
Same author

Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer.

Research square·2026
Same author

The gut microbiota-bile acid axis in liver transplantation: implications for postoperative complications and therapeutic strategies.

Frontiers in microbiology·2026
Same author

Ultrasound assisted preparation of Ti<sub>3</sub>C<sub>2</sub>Tx MXene/carbon nanotube/MnO<sub>2</sub> ternary composite with superior capacitive properties.

Ultrasonics sonochemistry·2026
Same author

Habitat suitability for the soybean aphid, <i>Aphis glycines</i>, and its natural enemies: implications for biological control and soybean protection.

Frontiers in plant science·2026
Same author

Mechanistic insights into the molecular selectivity and cotransport dynamics of biodegradable microplastic-derived DOM with cadmium in saturated porous media.

Journal of hazardous materials·2026

Related Experiment Video

Updated: Jun 14, 2025

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.4K

Exploring Predictive and Prognostic Biomarkers in Colorectal Cancer: A Comprehensive Review.

Karam Ashouri1, Alexandra Wong1, Pooja Mittal1

  • 1Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

Cancers
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Personalized medicine for colorectal cancer (CRC) requires new biomarkers. This review covers established and emerging markers, including KRAS, HER2, and liquid biopsies, to guide targeted therapies and improve patient outcomes.

Keywords:
colorectal cancergene expression profilingmolecular targeted therapytumor biomarkers

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

229
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

13.9K

Related Experiment Videos

Last Updated: Jun 14, 2025

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.4K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

229
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

13.9K

Area of Science:

  • Oncology
  • Genetics
  • Translational Medicine

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
  • Current immunotherapies are effective only for a subset of patients (MSI-H/dMMR tumors).
  • Personalized medicine in CRC necessitates identification of predictive biomarkers for targeted treatment strategies.

Purpose of the Study:

  • To provide a comprehensive review of the current biomarker landscape in colorectal cancer.
  • To discuss established and emerging biomarkers, including KRAS, HER2, and liquid biopsies.
  • To highlight challenges and future directions in translating biomarkers into clinical practice for enhanced personalized medicine.

Main Methods:

  • Literature review of established and emerging biomarkers in colorectal cancer.
  • Analysis of the role of KRAS and HER2 in anti-EGFR therapy resistance.
  • Synthesis of data on novel therapeutic targets and the clinical utility of liquid biopsies.

Main Results:

  • Established markers like KRAS and HER2 influence resistance to anti-EGFR therapies, with targeted treatments advancing.
  • Promising new therapeutic targets and the clinical value of liquid biopsies are emerging.
  • Current evidence highlights knowledge gaps in biomarker application for personalized CRC treatment.

Conclusions:

  • A contemporary understanding of the CRC biomarker landscape is crucial for clinicians and researchers.
  • Translating novel biomarkers into clinical practice remains a key challenge.
  • Enhanced personalized medicine approaches are essential to improve outcomes for colorectal cancer patients.