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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Transducer Mechanism: Nuclear Receptors01:31

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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Signal Transduction: Overview01:26

Signal Transduction: Overview

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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Long Non-Coding RNAs, Nuclear Receptors and Their Cross-Talks in Cancer-Implications and Perspectives.

Prabha Tiwari1, Lokesh P Tripathi2,3

  • 1Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.

Cancers
|August 29, 2024
PubMed
Summary

Long non-coding RNAs (lncRNAs) and nuclear receptors (NRs) are crucial in cellular processes and cancer. Their crosstalk significantly impacts cancer progression, offering potential as biomarkers and therapeutic targets.

Keywords:
biological cross-talkscancercancer signalinggene regulationgene regulatory networkslncRNAnon-coding RNAnuclear receptors

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Biology

Background:

  • Long non-coding RNAs (lncRNAs) regulate gene expression and cellular functions.
  • Nuclear Receptors (NRs) are ligand-regulated transcription factors involved in numerous cellular processes and diseases.
  • lncRNA-NR crosstalk is increasingly recognized in cellular regulation and disease, particularly cancer.

Purpose of the Study:

  • To review the roles of lncRNAs and NRs in cancer.
  • To explore the involvement of lncRNA-NR crosstalk in cancer progression and metastasis.
  • To discuss challenges and strategies for characterizing lncRNA-NR associations.

Main Methods:

  • Literature review of lncRNA and NR functions in cancer.
  • Analysis of lncRNA-NR interactions in cancer progression.
  • Discussion of methodologies for studying lncRNA-NR associations.

Main Results:

  • lncRNAs and NRs individually play significant roles in various cancers.
  • lncRNA-NR crosstalk influences cancer progression and metastasis.
  • Understanding these interactions is key for developing cancer biomarkers and therapies.

Conclusions:

  • lncRNA-NR interactions are critical in cancer biology.
  • Characterizing these associations presents challenges but offers significant potential.
  • Further research into lncRNA-NR mechanisms can lead to novel prognostic, diagnostic, and therapeutic strategies in oncology.