Supercritical Fluids: An Innovative Strategy for Drug Development

Area of Science:

• Biomedical Nanotechnology
• Green Chemistry in Drug Development
• Supercritical Fluid Applications

Background:

• Nanotechnology is crucial for regulating drug particle size, enhancing bioavailability.
• Traditional methods like milling and crystallization face challenges such as thermal degradation and solvent residue.
• Supercritical fluid technology presents a sustainable alternative for drug formulation.

Purpose of the Study:

• To explore the application of super-stable homogeneous intermix formulating technology (SHIFT) and super-table pure-nanomedicine formulation technology (SPFT) for drug dispersion and micronization.
• To investigate the impact of supercritical fluid-based technologies on drug solubility, permeability, and therapeutic efficacy.
• To highlight the advantages of these green drug development strategies over conventional methods.

Main Methods:

• Utilizing supercritical fluid technology to develop SHIFT and SPFT for drug formulation.
• Controlling drug particle size and morphology through these advanced techniques.
• Evaluating the therapeutic efficacy of modified drugs in preclinical models for conditions like cancer and neovascularization.

Main Results:

• SHIFT and SPFT significantly enhanced the solubility and permeability of hydrophobic drugs.
• Controlled particle size and morphology led to improved drug performance.
• Modified drugs demonstrated excellent therapeutic efficacy in treating hepatocellular carcinoma, pathological scarring, and corneal neovascularization across multiple administration routes.

Conclusions:

• Supercritical fluid technology provides a green and efficient pathway for advanced drug development.
• These novel formulation technologies can reduce drug side effects and improve therapeutic outcomes.
• The developed nanomedicine formulations show promise for clinical applications.