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Related Concept Videos

Supercritical Fluid Chromatography01:18

Supercritical Fluid Chromatography

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Supercritical fluid chromatography (SFC) provides a beneficial substitute for gas chromatography (GC) and liquid chromatography (LC) for certain samples because it merges the top attributes of both techniques. SFC allows the separation and analysis of compounds that GC or LC does not easily manage. These compounds are traditionally nonvolatile or thermally unstable, making GC unsuitable and lacking functional groups required for HPLC analysis.
SFC utilizes a supercritical fluid mobile phase,...
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Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Supercritical Nitrogen Processing for the Purification of Reactive Porous Materials
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Supercritical Fluids: An Innovative Strategy for Drug Development.

Hui Liu1, Xiaoliu Liang1, Yisheng Peng1

  • 1State Key Laboratory of Vaccine for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China.

Bioengineering (Basel, Switzerland)
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PubMed
Summary

Supercritical fluid technology offers a green approach to drug development, enhancing bioavailability by precisely controlling particle size. Novel technologies like SHIFT and SPFT improve hydrophobic drug efficacy for various conditions.

Keywords:
bioavailabilityclinical applicationdrug deliverynanomedicinesupercritical fluid technology

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Area of Science:

  • Biomedical Nanotechnology
  • Green Chemistry in Drug Development
  • Supercritical Fluid Applications

Background:

  • Nanotechnology is crucial for regulating drug particle size, enhancing bioavailability.
  • Traditional methods like milling and crystallization face challenges such as thermal degradation and solvent residue.
  • Supercritical fluid technology presents a sustainable alternative for drug formulation.

Purpose of the Study:

  • To explore the application of super-stable homogeneous intermix formulating technology (SHIFT) and super-table pure-nanomedicine formulation technology (SPFT) for drug dispersion and micronization.
  • To investigate the impact of supercritical fluid-based technologies on drug solubility, permeability, and therapeutic efficacy.
  • To highlight the advantages of these green drug development strategies over conventional methods.

Main Methods:

  • Utilizing supercritical fluid technology to develop SHIFT and SPFT for drug formulation.
  • Controlling drug particle size and morphology through these advanced techniques.
  • Evaluating the therapeutic efficacy of modified drugs in preclinical models for conditions like cancer and neovascularization.

Main Results:

  • SHIFT and SPFT significantly enhanced the solubility and permeability of hydrophobic drugs.
  • Controlled particle size and morphology led to improved drug performance.
  • Modified drugs demonstrated excellent therapeutic efficacy in treating hepatocellular carcinoma, pathological scarring, and corneal neovascularization across multiple administration routes.

Conclusions:

  • Supercritical fluid technology provides a green and efficient pathway for advanced drug development.
  • These novel formulation technologies can reduce drug side effects and improve therapeutic outcomes.
  • The developed nanomedicine formulations show promise for clinical applications.