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Deficient or Normal Growth Hormone Secretion in Polish Children with Short Stature: Searching for Clinical

Katarzyna Anna Majewska1, Magdalena Tchorzewska-Skrobich1, Paulina Wais1

  • 1Department of Pediatric Diabetes, Auxology and Obesity, Poznan University of Medical Sciences, 60-572 Poznan, Poland.

Biomedicines
|August 29, 2024
PubMed

Insights

Clinical characteristics of short stature children in Poland revealed no significant differences between those with growth hormone deficiency (GHD) and normal growth hormone secretion (GHN). This suggests the 10 ng/mL cutoff may not be clinically relevant for diagnosis.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Child Health

Background:

  • Short stature affects 2.5% of children, with growth hormone deficiency (GHD) sometimes treated with recombinant human growth hormone (rhGH).
  • Diagnostic standards for GHD can be controversial, necessitating further data for refined recommendations.

Purpose of the Study:

  • To analyze the clinical characteristics of Polish children with short stature.
  • To evaluate the relevance of current GHD diagnostic standards using a 10 ng/mL peak growth hormone (GH) cutoff.

Main Methods:

  • Retrospective analysis of 277 short stature children.
  • Division into GHD (peak GH < 10 ng/mL) and normal GH secretion (GHN) subgroups.
  • Comparison of clinical data including gender, birth weight, bone age, height SDS, IGF-1 SDS, vitamin D, celiac indices, hypothyroidism, and anemia.

Main Results:

  • No significant differences were observed between GHD and GHN subgroups across all analyzed clinical variables.
  • Key parameters like gender, birth weight, bone age delay, height SDS, IGF-1 SDS, and prevalence of comorbidities showed no distinction.

Conclusions:

  • The findings indicate substantial clinical overlap between children diagnosed with GHD and those with normal GH secretion based on the 10 ng/mL cutoff.
  • The clinical relevance of distinguishing between GHD and GHN using this specific cutoff value appears questionable.

Keywords:
childrengrowth hormonegrowth hormone deficiencyshort stature

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