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Published on: August 8, 2022
Ceruloplasmin and Lipofuscin Serum Concentrations Are Associated with Presence of Hypertrophic Cardiomyopathy
Wiktoria Smyła-Gruca1, Wioletta Szczurek-Wasilewicz2, Michał Skrzypek3
1Student's Scientific Society, 3rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Insights
Oxidative stress markers, ceruloplasmin (CER) and lipofuscin (LPS), show promise in detecting hypertrophic cardiomyopathy (HCM). Superoxide dismutase (SOD) had limited utility for HCM diagnosis.
Area of Science:
- Cardiology
- Biochemistry
- Pathophysiology
Background:
- Oxidative stress, an imbalance between reactive oxygen species and antioxidant defenses, is implicated in various diseases.
- Its specific role in hypertrophic cardiomyopathy (HCM) remains unclear, necessitating further investigation.
Purpose of the Study:
- To investigate selected oxidative stress markers in patients diagnosed with HCM compared to a healthy control group.
- To evaluate the diagnostic potential of these markers for HCM detection.
Main Methods:
- The study included 85 HCM patients and 97 controls, matched for age, sex, and body mass index.
- Key oxidative stress markers measured were superoxide dismutase (SOD), ceruloplasmin (CER), and lipofuscin (LPS).
- Receiver operating characteristic (ROC) curve analysis was employed to assess discriminatory power.
Main Results:
- HCM patients exhibited significantly elevated levels of CER and LPS compared to controls.
- CER demonstrated strong discriminatory power for HCM (AUC 0.924), while LPS showed acceptable power (AUC 0.740).
- SOD displayed poor discriminatory ability (AUC 0.556) in detecting HCM.
Conclusions:
- Ceruloplasmin and lipofuscin show potential as biomarkers for detecting hypertrophic cardiomyopathy.
- Superoxide dismutase has limited clinical utility for diagnosing HCM.
- These findings contribute to understanding oxidative stress in HCM pathophysiology.
Abstract:
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and cells' ability to neutralize them by antioxidant systems. The role of oxidative stress in hypertrophic cardiomyopathy (HCM) is not fully understood. The aim of the study was to examine selected parameters of oxidative stress in patients with HCM compared to the control group. We enrolled 85 consecutive HCM patients and 97 controls without HCM. The groups were matched for sex, the body mass index, and age. Oxidative stress markers included superoxide dismutase (SOD), ceruloplasmin (CER), and lipofuscin (LPS). The median age of the HCM patients was 53 (40-63) years, and 41.2% of them were male. HCM patients, compared to the control ones, had significantly increased levels of CER and LPS. The areas under the receiver operating characteristics curves (AUC) indicated a good discriminatory power of CER (AUC 0.924, sensitivity 84%, and specificity 88%), an acceptable discriminatory power of LPS (AUC 0.740, sensitivity 66%, and specificity 72%), and poor discriminatory power of SOD (AUC 0.556, sensitivity 34%, and specificity 94%) for HCM detection. CER with good predictive strength, as well as LPS with acceptable predictive power, allows for HCM detection. The utility of SOD for HCM detection is limited.
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