Cerebrospinal Fluid Total and Phosphorylated Tau Protein in Behavioral Variant Frontotemporal Dementia, Progressive Supranuclear Palsy, Corticobasal Syndrome and Non-Fluent Agrammatic Primary Progressive Aphasia: A Systematic Review and Meta-Analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Cerebrospinal fluid (CSF) phosphorylated tau (p-tau) may be decreased in tauopathies, while total tau (t-tau) is increased in frontotemporal lobar degeneration (FTLD) subtypes. Alzheimer's disease (AD) admixture and study heterogeneity complicate FTLD research.
Area Of Science
- Neuroscience
- Biochemistry
- Clinical Neurology
Background
- Frontotemporal lobar degeneration (FTLD) encompasses diverse tauopathies like Pick's disease, progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD).
- These conditions manifest in distinct syndromes: behavioral variant frontotemporal dementia (bvFTD), Richardson syndrome (RS), corticobasal syndrome (CBS), and non-fluent agrammatic primary progressive aphasia (nfa-PPA).
Purpose Of The Study
- To evaluate the diagnostic utility of cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau (p-tau) in distinguishing FTLD subtypes and tauopathies.
- To analyze CSF t-tau and p-tau levels in patients with bvFTD, RS, CBS, nfa-PPA, and pathologically confirmed tauopathies compared to controls.
Main Methods
- A systematic review and meta-analysis of studies with over 10 subjects per group.
- Inclusion of studies with available CSF t-tau or p-tau mean and standard deviation data.
- Quantification of effect sizes using Cohen's d.
Main Results
- Patients with PSP and other tauopathies showed decreased CSF p-tau levels relative to controls.
- Cohorts with CBS, bvFTD, and nfa-PPA demonstrated elevated CSF t-tau levels compared to control groups.
Conclusions
- A potential intrinsic decrease in CSF p-tau may characterize tauopathies.
- Confounding factors in FTLD research include the presence of Alzheimer's disease (AD) patients in FTD cohorts and significant heterogeneity in studies of rare diseases.
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