Related Experiment Video

Updated: Jun 14, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.8K

The Association between Cardiovascular Risk Factors and Lichen Sclerosus: A Systematic Review and Meta-Analysis

Suvijak Untaaveesup1, Piyawat Kantagowit2, Nattawut Leelakanok3

  • 1Phaholpolpayuhasena Hospital, Kanchanaburi 71000, Thailand.

Journal of Clinical Medicine
|August 29, 2024
PubMed

Insights

Lichen sclerosus is linked to type 2 diabetes mellitus. This condition may also correlate with hypertension, dyslipidemia, obesity, and metabolic syndrome, warranting further research.

Area of Science:

  • Dermatology
  • Cardiology
  • Epidemiology

Background:

  • Lichen sclerosus is a chronic inflammatory skin condition affecting diverse populations.
  • Previous studies suggest links between lichen sclerosus and cardiovascular risk factors, but evidence remains inconclusive.
  • Clarifying these associations is crucial for comprehensive patient management.

Purpose of the Study:

  • To conduct a meta-analysis synthesizing the current evidence on the association between cardiovascular risk factors and lichen sclerosus.
  • To provide a quantitative summary of the relationship between lichen sclerosus and conditions like diabetes, hypertension, and dyslipidemia.

Main Methods:

  • Systematic literature search of MEDLINE and EMBASE databases up to May 2024.
  • Inclusion of 16 studies (9 case-control, 6 retrospective cohort, 1 cross-sectional) involving 432,457 participants.
  • Application of a random-effects model for meta-analysis.

Main Results:

  • A significant association was found between lichen sclerosus and type 2 diabetes mellitus (OR: 2.07; 95% CI: 1.21-3.52).
  • Trends suggesting increased risk were observed for hypertension (OR: 1.56), dyslipidemia (OR: 1.44), and metabolic syndrome (OR: 1.36), though not statistically significant.
  • Obesity showed a wide confidence interval (OR: 5.84; 95% CI: 0.37-92.27), indicating limited statistical power.

Conclusions:

  • Lichen sclerosus is significantly associated with type 2 diabetes mellitus.
  • Potential correlations exist between lichen sclerosus and hypertension, dyslipidemia, obesity, and metabolic syndrome.
  • Further population-based prospective studies are recommended to confirm these associations and their clinical implications.

Keywords:
diabetes mellitusdyslipidemiahypertensionmetabolic syndromeobesityvulvar lichen sclerosus

More Related Videos

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.8K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

824

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
27
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
291
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
68
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
708