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Updated: Jun 14, 2025

Author Spotlight: Investigating Angiogenesis Through Challenges and Innovations in Assay Development
Published on: May 31, 2024
New Interpretations for Sprouting, Intussusception, Ansiform, and Coalescent Types of Angiogenesis
Alexander V Korablev1, Irina S Sesorova2, Vitaly V Sesorov2
1Department of Pathological Anatomy, Yaroslavl State Medical University, Yaroslavl 150000, Russia.
Abstract:
Angiogenesis, or the development of blood vessels by growing from already-formed vessels, is observed in embryonic development, physiological cyclical processes such as wound healing, the encapsulation of foreign bodies, tumor growth, and some other situations. In this review, we analyze the cellular mechanisms of angiogenesis, namely, angiogenesis by sprouting, ansiform (by loop formation) angiogenesis, coalescent angiogenesis, and angiogenesis by intussusception (splitting the capillary into two channels). The analysis of data revealed a lot of unanswered questions and contradictions. Here, we propose several new models of angiogenesis explaining these contradictions.
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