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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Phenotyping Tumor Heterogeneity through Proteogenomics: Study Models and Challenges.

Diletta Piana1,2, Federica Iavarone1,2, Elisa De Paolis2,3

  • 1Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

International Journal of Molecular Sciences
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Tumor heterogeneity, the diversity within and between tumors, requires advanced methods like proteogenomics. This approach integrates genomics and proteomics to reveal molecular and phenotypic features for better diagnostics and therapeutics.

Keywords:
cancerpersonalized medicineproteogenomicsproteomics

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Area of Science:

  • Oncology
  • Genomics
  • Proteomics
  • Biomarker Discovery

Background:

  • Tumor heterogeneity, encompassing inter- and intra-tumor variations, presents distinct cellular morphologies and treatment responses.
  • Understanding tumor heterogeneity is crucial for identifying tumor-specific mechanisms for diagnostic and therapeutic advancements.
  • Multidisciplinary approaches are essential for characterizing complex tumor features.

Purpose of the Study:

  • To review the impact of proteogenomics in characterizing tumor phenotypes.
  • To highlight the challenges and limitations of proteogenomics in clinical and preclinical models.
  • To explore the potential of proteogenomics in identifying therapeutic biomarkers.

Main Methods:

  • Proteogenomics integrates genomics (Next-Generation Sequencing) and proteomics (mass spectrometry).
  • This multidisciplinary approach provides a comprehensive view of tumor heterogeneity.
  • Analysis focuses on molecular alterations and phenotypic features.

Main Results:

  • Proteogenomics offers a comprehensive view of tumor heterogeneity by combining omics data.
  • It reveals molecular alterations and phenotypic features linked to tumor subtypes.
  • Potential therapeutic biomarkers can be identified through this integrated approach.

Conclusions:

  • Proteogenomics is a powerful tool for understanding tumor heterogeneity and its phenotypic characteristics.
  • Despite advances, challenges in sensitivity, specificity, and study models persist.
  • Further development is needed to fully leverage proteogenomics for cancer diagnostics and therapeutics.