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Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis.

Jae Heon Kim1,2, Hoonhee Seo3, Sukyung Kim3

  • 1Department of Urology, Soonchunhyang University School of Medicine, Seoul 04401, Republic of Korea.

International Journal of Molecular Sciences
|August 29, 2024
PubMed
Summary

Prostate cancer

Keywords:
Cutibacteriumbiomarkerhigh-grade prostate tumor (HGT)low-grade prostate tumor (LGT)prostate cancertherapeutic targets

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Area of Science:

  • Microbiology
  • Oncology
  • Genomics

Background:

  • Human pathologies, including neoplasia, are linked to specific bacteria and microbiome alterations.
  • Understanding the role of the microbiome in prostate cancer is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the association between bacterial imbalance and prostate carcinoma.
  • To compare microbiome and gene functionality in high-grade prostate tumor (HGT) and low-grade prostate tumor (LGT) tissues.

Main Methods:

  • Next-generation sequencing (NGS) technology was employed to analyze microbiome and gene functionality.
  • Bacterial profiles and gene functions were compared between HGT and LGT specimens.
  • Cell proliferation and cytokine assays were conducted.

Main Results:

  • Significant abnormalities in bacterial profiles were observed between HGT and LGT specimens.
  • HGT specimens exhibited higher frequencies of Cutibacterium, Pelomonas, and Corynebacterium genera.
  • Cutibacterium exposure led to increased prostate cancer cell proliferation and elevated cytokine levels.

Conclusions:

  • Distinct bacterial populations characterize high-grade and low-grade prostate malignancies.
  • Microbiome alterations may play a role in prostate cancer progression.
  • Further research into the specific roles of bacteria like Cutibacterium in prostate cancer is warranted.