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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

691
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
691
T Cell Types and Functions01:24

T Cell Types and Functions

963
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
963

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Related Experiment Video

Updated: Jun 14, 2025

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
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Current Knowledge about CD3+CD20+ T Cells in Patients with Multiple Sclerosis.

Borros Arneth1,2

  • 1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Justus Liebig University Giessen, Feulgenstr. 12, 35392 Giessen, Germany.

International Journal of Molecular Sciences
|August 29, 2024
PubMed
Summary

CD3+CD20+ T cells are present in multiple sclerosis patients, indicating disease chronicity. Their presence in cerebrospinal fluid suggests a role in therapeutic efficacy and disease activity.

Keywords:
CD20-expressingCD3+CD20+ T cellsCNSmultiple sclerosispathogenesisrituximab

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Area of Science:

  • Neuroimmunology
  • Cellular Immunology

Background:

  • Multiple sclerosis (MS) is a central nervous system autoimmune disease.
  • T cells expressing CD20, typically a B-cell marker, are observed in MS patients.

Purpose of the Study:

  • To review the role of CD3+CD20+ T cells in multiple sclerosis.
  • To investigate the significance of these cells in disease activity and therapeutic response.

Main Methods:

  • Systematic literature review of PubMed and CINAHL (2014-2024).
  • Search terms included MS, CD3+CD20+ T cells, incidence, significance, and rituximab treatment.

Main Results:

  • CD3+CD20+ T cells are consistently found in the cerebrospinal fluid of MS patients.
  • These cells are associated with disease chronicity and high disease activity.
  • Emerging evidence links CD20-expressing T cells to MS therapeutic targets and efficacy.

Conclusions:

  • CD3+CD20+ T cells are a significant biomarker in multiple sclerosis.
  • Their presence in cerebrospinal fluid correlates with disease severity and may influence treatment strategies.