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The Association between Telomere Length and Head and Neck Cancer Risk: A Systematic Review and Meta-Analysis.

Dimitrios Andreikos1, Efthymios Kyrodimos2, Athanassios Kotsinas3

  • 1School of Medicine, Democritus University of Thrace, 68100 Alexandroupoli, Greece.

International Journal of Molecular Sciences
|August 29, 2024
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Short telomere length (TL) is linked to a higher risk of head and neck cancer (HNC). This meta-analysis suggests TL may serve as a potential biomarker for HNC risk, warranting further investigation.

Keywords:
associationcancerhead and neck cancermeta-analysistelomeretelomere length

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Area of Science:

  • Genetics and Molecular Biology
  • Oncology
  • Cellular Aging

Background:

  • Telomeres are critical for chromosomal stability and cell division, influencing cellular aging.
  • Telomere length (TL) associations with various cancers are inconsistent.
  • Head and neck cancer (HNC) risk factors require further elucidation.

Conclusions:

  • Short TL is associated with an elevated risk of head and neck cancer.
  • TL may function as a potential biomarker for HNC risk.
  • High-quality prospective studies are essential to confirm these findings and validate TL as a biomarker.