Bactericidal activity of phenoxymethylpenicillin in an in-vitro model simulating tissue kinetics

The antibacterial efficacy of phenoxymethylpenicillin (Pen-V-K) against strains of Staphylococcus aureus was assessed in an in-vitro kinetic model. Simulation was based on human serum levels and tissue water curves obtained after a single oral dose of 392.2 mg of the drug. Differences in bacterial elimination kinetics were noted depending upon the type of curve (serum or tissue water) being simulated.