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Simethicone Medication Should Be Avoided in Infants Receiving Oral Lactase Treatment

Ekin Say Yildirim1, Adem Aydin1, Tolga Ince1

  • 1Department of Pediatrics, Faculty of Medicine, Dokuz Eylül University, 35340 İzmir, Türkiye.

Children (Basel, Switzerland)
|August 29, 2024
PubMed

Insights

Oral lactase effectively treats infant lactose intolerance in most cases. However, its efficacy may be reduced when given with simethicone for colic, suggesting a potential drug interaction.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Pharmacology

Background:

  • Infant lactose intolerance is a common condition.
  • Oral lactase supplementation is a potential treatment.
  • Understanding factors affecting lactase efficacy is crucial.

Purpose of the Study:

  • To evaluate the efficacy of oral lactase in infants diagnosed with lactose intolerance.
  • To assess the influence of sex, birth weight, and concomitant medications on lactase treatment outcomes.
  • To identify potential drug interactions affecting oral lactase effectiveness.

Main Methods:

  • Retrospective study of infants aged 0-6 months diagnosed with lactose intolerance.
  • Data collection included demographic information, symptom onset, and medications used.
  • Analysis of treatment response based on patient characteristics and co-administered drugs.

Main Results:

  • 86.7% of infants showed a positive response to oral lactase.
  • No significant differences in efficacy were observed based on sex, birth weight, or age at symptom onset.
  • Lactase efficacy improved over time, likely due to intestinal development.
  • Concomitant use of simethicone reduced lactase response, indicating a potential drug interaction.
  • Probiotics did not impact the effectiveness of oral lactase treatment.

Conclusions:

  • Oral lactase is an effective treatment for infant lactose intolerance.
  • Simethicone co-administration may decrease oral lactase efficacy.
  • Avoid using additional medications like simethicone concurrently with oral lactase to ensure optimal treatment outcomes.
Abstract

Keywords:
infantlactaselactose intolerancesimethicone

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