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Updated: Jun 22, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

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Subcutaneous versus Transvenous Implantable Cardioverter Defibrillator in Patients with End-Stage Renal Disease

Fabian Schiedat1,2, Benjamin Meuterodt3, Joachim Winter4

  • 1Department of Cardiology and Angiology, Marienhospital Gelsenkirchen, Academic Hospital of the Ruhr University Bochum, 45886 Gelsenkirchen, Germany.

Journal of Personalized Medicine
|August 29, 2024
PubMed

Insights

Subcutaneous ICDs (S-ICD) show fewer infections and hospitalizations in dialysis patients compared to transvenous ICDs (TV-ICD). This suggests S-ICD may offer better long-term outcomes for this high-risk group.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Devices

Background:

  • Patients with end-stage renal disease (ESRD) on dialysis face high risks of infection and mortality with cardiac implantable electronic devices (CIEDs).
  • Comparing subcutaneous ICD (S-ICD) and transvenous ICD (TV-ICD) is crucial for optimizing care in this vulnerable population.

Purpose of the Study:

  • To compare long-term complications and outcomes between S-ICD and TV-ICD recipients with ESRD requiring dialysis.
  • To evaluate device-associated infections, hospitalizations, and mortality rates in these patient groups.

Main Methods:

  • A retrospective analysis of 43 ESRD patients on dialysis who received either S-ICD (26) or TV-ICD (17).
  • Bi-annual follow-up over a median of 95.6 months, confirming data with treating physicians.

Main Results:

  • TV-ICD recipients experienced significantly more device-associated infections (HR 8.72) and hospitalizations (HR 10.20).
  • Cardiovascular mortality was higher in the TV-ICD group (HR 9.17), with more overall hospitalizations (HR 2.59).
  • No significant difference in overall mortality was observed between the S-ICD and TV-ICD groups.

Conclusions:

  • S-ICD implantation is associated with statistically fewer device infections and hospitalizations in ESRD patients on dialysis.
  • S-ICD may be a safer alternative, offering lower cardiac mortality compared to TV-ICD in this high-risk cohort.
Abstract

Keywords:
CIED infectionS-ICDTV-ICDend-stage renal diseasehemodialysisimplantable cardiac defibrillatorsudden cardiac death

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