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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Updated: Jun 14, 2025

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Elevating Skincare Science: Grape Seed Extract Encapsulation for Dermatological Care.

Maria Leonor Castro1, João Azevedo-Silva1,2, Diana Valente1,2

  • 1CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

Molecules (Basel, Switzerland)
|August 29, 2024
PubMed
Summary

Grape seed extracts, rich in bioactive polyphenols, were encapsulated into microdispersions for skincare applications. These stabilized extracts demonstrated antioxidant, antimicrobial, and anti-inflammatory properties, offering a sustainable solution for skin health.

Keywords:
grape by-productsmicrodispersionsphenolic compoundsskincaresustainability

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Area of Science:

  • Cosmetic Science
  • Biotechnology
  • Food Science

Background:

  • The skin's integrity is crucial for its protective functions, driving innovation in cosmetic science.
  • Plant-derived compounds, particularly from grape by-products, offer bioactive potential for skincare.
  • Instability of key molecules like phenolic compounds necessitates advanced delivery systems such as microdispersions.

Purpose of the Study:

  • To evaluate grape seed extracts (GSE) for cosmetic applications.
  • To encapsulate a selected GSE into soy lecithin microdispersions for enhanced stability and delivery.
  • To assess the safety and bioactivity of the encapsulated GSE microdispersions.

Main Methods:

  • Two grape seed extracts (GSE-Ov and GSE-Sv) were prepared and analyzed for chemical composition, antioxidant, and antimicrobial activities.
  • The most potent extract (GSE-Ov) was encapsulated in pectin-coated soy lecithin microdispersions.
  • Encapsulation efficiency, in vitro polyphenol release, particle characteristics (zeta potential, diameter), cell safety (HaCaT, HDF), and anti-inflammatory effects (IL-1α) were evaluated.

Main Results:

  • GSE-Ov exhibited significant antioxidant activity (DPPH IC50 of 0.079 mg mL-1).
  • Encapsulation achieved 88.8% efficiency, with 59.4% polyphenol release over 24 hours.
  • Microdispersions were safe in cell models and demonstrated anti-inflammatory effects.

Conclusions:

  • Grape seed extracts can be effectively stabilized and delivered via microdispersions for skincare.
  • This approach valorizes wine industry by-products into functional cosmetic ingredients.
  • Encapsulated GSE holds promise for promoting skin health through antioxidant and anti-inflammatory mechanisms.