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Phytocompounds and Nanoformulations for Anticancer Therapy: A Review.

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Natural compounds from plants show promise against cancer. Nanoformulations can improve their delivery and effectiveness, overcoming limitations of conventional treatments and enhancing anticancer therapy.

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Area of Science:

  • Oncology
  • Pharmacology
  • Nanotechnology

Background:

  • Conventional cancer treatments have significant limitations, including toxicity and drug resistance.
  • Plant-derived natural products (phytocompounds) exhibit promising anticancer properties with lower toxicity.
  • Challenges such as poor solubility and bioavailability hinder the clinical application of phytocompounds.

Purpose of the Study:

  • To review phytocompounds and their nanoformulations with demonstrated antitumor activities.
  • To examine the mechanisms of action of phytocompounds against various cancers.
  • To discuss the advantages of nanoformulations in overcoming phytocompound delivery limitations.

Main Methods:

  • Review of in vitro and in vivo studies on selected phytocompounds and their nanoformulations.
  • Analysis of intracellular pathways involved in phytocompound anticancer effects.
  • Examination of clinical translation challenges for phytocompounds and nanoformulations.

Main Results:

  • Phytocompounds like curcumin, resveratrol, and quercetin show significant in vitro and in vivo anticancer activity.
  • Nanoformulations enhance the solubility, stability, and targeted delivery of these compounds.
  • Nanoformulations improve the therapeutic efficacy of phytocompounds against diverse cancers.

Conclusions:

  • Phytocompounds and their nanoformulations represent a promising strategy for novel anticancer therapies.
  • Overcoming formulation and delivery challenges is crucial for clinical success.
  • Further research is needed to bridge the gap between preclinical findings and clinical application.