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Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction
Marcos Díaz-Fernández1,2, Manuel Algarra3, Saturnino Calvo-Losada2
1Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.
Abstract:
The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.
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