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The Role of Akkermansia muciniphila on Improving Gut and Metabolic Health Modulation: A Meta-Analysis of Preclinical

Leila Khalili1, Gwoncheol Park1, Ravinder Nagpal1

  • 1Department of Health, Nutrition and Food Sciences, Florida State University, Tallahassee, FL 32306, USA.

Microorganisms
|August 29, 2024
PubMed

Insights

Akkermansia muciniphila and its derivatives improve gut health and metabolic function by enhancing gut barrier integrity and modulating inflammation. Live bacteria showed greater benefits, suggesting combined use with specific gut microbes may optimize health outcomes.

Area of Science:

  • Microbiome research
  • Gastroenterology
  • Metabolic health

Background:

  • Akkermansia muciniphila (A. muciniphila) and its derivatives are known for improving intestinal balance and metabolic health.
  • Mechanisms of A. muciniphila's action and its microbiome effects require further elucidation.

Purpose of the Study:

  • To investigate the influence of A. muciniphila and its derivatives on gastrointestinal (GI) and metabolic disorders.
  • To analyze effects through a meta-analysis of mouse model studies.

Main Methods:

  • Meta-analysis of 39 studies on mouse models of GI and metabolic disorders.
  • Searches conducted on PubMed, Web of Science, Science Direct, and Embase until May 2024.
  • Analysis of A. muciniphila (alive or heat-killed) and its derivatives' impact on various biomarkers and gut microbiome.

Main Results:

  • A. muciniphila and derivatives improved gut barrier function by increasing tight-junction proteins.
  • Positive effects observed on systemic/gut inflammation, liver enzymes, glycemic response, and lipid profiles.
  • Live bacteria demonstrated more significant biomarker improvements; specific microbial clusters co-occurred with live A. muciniphila.

Conclusions:

  • A. muciniphila and its derivatives show therapeutic potential for GI and metabolic disorders.
  • Enhancing A. muciniphila and associated gut microbial clusters may offer superior health benefits for cardiometabolic and age-related diseases.
  • Findings provide mechanistic insights for future translational applications in human health.
Keywords:
Akkermansia muciniphilaCandidatus SaccharimonasDesulfovibrioFamily XIII AD3011 groupgutinflammationmetabolic health

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