Related Experiment Video
Updated: Jun 14, 2025
07:15
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
9.5K
Functional Abdominal Bloating and Gut Microbiota: An Update
Salvatore Crucillà1, Federico Caldart1, Marco Michelon2
1Gastroenterology B Unit, Pancreas Center, University of Verona, 37134 Verona, Italy.
Microorganisms
|August 29, 2024
Summary
Restoring gut microbiota balance is key for managing functional abdominal bloating and distension (FAB/FAD). Targeted therapies like probiotics, prebiotics, and antibiotics show promise for symptom relief.
Area of Science:
- Gastroenterology
- Microbiome Research
- Gut-Brain Interaction
Background:
- Functional abdominal bloating and distension (FAB/FAD) are common gut-brain interaction disorders.
- Their complex pathophysiology involves gut microbiota imbalances.
- Current treatments for FAB/FAD remain a clinical challenge.
Purpose of the Study:
- To review current evidence on FAB/FAD, focusing on the role of gut microbiota.
- To explore the potential of microbiota modulation strategies in managing FAB/FAD.
Main Methods:
- A narrative review of English-edited studies was conducted in October 2023.
- Literature search performed across Medline, PubMed, and Embase databases.
- Included RCTs, cross-sectional, cohort, and case-control studies.
Main Results:
- Twelve studies were selected, primarily linking Irritable Bowel Syndrome (IBS) and microbiota.
- Restoring a balanced microbiome is the most promising strategy for FAB/FAD management.
- Probiotics, prebiotics, rifaximin, and dietary changes may alleviate symptoms.
Conclusions:
- Targeted gut microbiota interventions (probiotics, prebiotics, antibiotics) are essential for FAB/FAD.
- Understanding the gut microbiota-FAB/FAD relationship is crucial for effective treatment development.
- Further research is needed to elucidate specific microbial roles in FAB/FAD.
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