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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

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Parvovirus B19 in Rheumatic Diseases.

Rosaria Arvia¹, Maria A Stincarelli¹, Elisabetta Manaresi²

¹Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

|August 29, 2024

Summary

Parvovirus B19 (B19V) causes various diseases by infecting erythroid progenitor cells. This review explores B19V

Keywords:

B19V arthritis human parvovirus B19 rheumatologic diseases systemic lupus erythematosus systemic sclerosis

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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

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Published on: April 4, 2019

Area of Science:

Virology and Immunology
Rheumatology

Background:

Parvovirus B19 (B19V) is a widespread human pathogen in the Parvoviridae family.
B19V infects erythroid progenitor cells (EPCs), causing apoptosis and diverse clinical manifestations.
It can also infect non-permissive cells, altering their physiology and contributing to pathogenesis.

Purpose of the Study:

To provide fundamental information on Parvovirus B19.
To highlight viral infection characteristics in permissive and non-permissive cellular systems.
To focus on recent findings regarding B19V's pathogenic role in rheumatologic diseases.

Main Methods:

Review of existing literature on Parvovirus B19.
Analysis of viral-cellular interactions in different cell types.
Synthesis of evidence linking B19V to autoimmune rheumatologic conditions.

Main Results:

B19V infection leads to EPC apoptosis and can affect other cell types.
Joint involvement is a common symptom in adult B19V infections.
Emerging evidence suggests B19V's potential role in rheumatoid arthritis, juvenile idiopathic arthritis, systemic sclerosis, SLE, and vasculitis.

Conclusions:

Parvovirus B19 exhibits diverse pathogenic mechanisms based on host cell interactions.
B19V is increasingly implicated in the pathogenesis of several autoimmune rheumatologic diseases.
Further research is warranted to elucidate the precise role of B19V in these conditions.