6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength

Area of Science:

• Nutrition Science
• Exercise Physiology
• Biochemistry

Background:

• Sialyllactose (SL) is a human milk oligosaccharide known for immune and developmental benefits.
• The impact of SL on exercise performance and muscle mass has not been previously studied.

Purpose of the Study:

• To investigate the effects of 6'-Sialyllactose (6'-SL) on muscle function and exercise capacity in mice.
• To determine if 6'-SL supplementation can enhance physical performance and muscle characteristics.

Main Methods:

• Male C57BL/6J mice were administered 100 mg/kg 6'-SL for 12 weeks.
• Exhaustive treadmill performance, grip strength, muscle mass, fiber size, and protein expression were assessed.

Main Results:

• 6'-SL administration significantly improved treadmill performance, increasing running distance and exhaustion time.
• Grip strength and muscle mass (gastrocnemius and soleus) were elevated in the 6'-SL group.
• Minimum Feret's diameter and total myosin heavy chain protein expression increased in the gastrocnemius muscle.

Conclusions:

• In vivo administration of 6'-SL enhances running performance and muscle strength.
• 6'-SL supplementation shows potential for improving muscle health and exercise capacity.