Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer

Area of Science:

• Oncology
• Nutritional Science
• Microbiome Research

Background:

• Breast cancer (BC) is a prevalent global cancer with significant mortality, necessitating advanced treatment strategies.
• BC development is influenced by genetic, lifestyle, and environmental factors, with nutrition and the gut microbiome emerging as key players.
• The gut microbiota's role in health and disease, including its association with BC risk and progression, is increasingly recognized.

Purpose of the Study:

• To review the impact of nutrition interventions on breast cancer (BC) prevention and treatment.
• To examine how dietary patterns, bioactive compounds, and nutrients modulate the gut microbiome in BC.
• To highlight microbiome-mediated mechanisms and discuss combined nutrition-microbe therapies for BC.

Main Methods:

• Literature review of animal and human studies on nutrition interventions in breast cancer (BC).
• Analysis of research on the effects of diet on gut microbiome composition and function.
• Exploration of the interplay between nutrition, the gut microbiome, and BC development and treatment.

Main Results:

• Nutrition interventions, including specific dietary patterns and compounds, can influence BC prevention and therapeutic outcomes.
• These interventions demonstrably modulate the gut microbiome's structure and activity.
• The nutrition-microbiome axis presents a significant pathway through which diet impacts BC.

Conclusions:

• Nutrition interventions are a vital component of comprehensive breast cancer (BC) management.
• Modulating the gut microbiome through diet offers a promising strategy for BC prevention and treatment.
• A holistic approach integrating nutrition and microbiome-targeted therapies is essential for effective BC care.