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Dietary Flavonoids: Mitigating Air Pollution's Cardiovascular Risks.
Oscar Andrés Rocha-Velasco1, María Morales-Suárez-Varela1,2, Agustín Llopis-González1,2
1Research Group in Social and Nutritional Epidemiology, Pharmacoepidemiology and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy and Food Sciences, Universitat de València, Av. Vicent Andrés Estelles s/n, 46100 Burjassot, Spain.
Dietary flavonoids may protect cardiovascular health from air pollution. Promoting flavonoid-rich diets is a promising complementary strategy to reduce pollution
Area of Science:
- Environmental Health
- Cardiovascular Medicine
- Nutritional Science
Background:
- Air pollution poses significant risks to cardiovascular health, with limited preventative strategies.
- Dietary flavonoids show potential for cardiovascular protection, but their role in mitigating air pollution's effects is unknown.
Purpose of the Study:
- To investigate the potential of dietary flavonoids in counteracting cardiovascular risks associated with air pollution exposure.
- To synthesize current evidence on the protective mechanisms and effects of flavonoids against air pollution-induced cardiovascular damage.
Main Methods:
- Systematic literature review following PRISMA-ScR guidelines (2014-2024).
- Searched MedLine/PubMed, ScienceDirect, and MDPI databases for relevant studies.
- Analyzed 53 eligible studies based on PICO criteria.
Main Results:
- Air pollution significantly increases cardiovascular disease risk and mortality.
- Flavonoid intake demonstrated protective cardiovascular effects, including improved endothelial function, antioxidant and anti-inflammatory actions, and better metabolic profiles.
- Higher flavonoid consumption was consistently linked to reduced cardiovascular risks.
Conclusions:
- Dietary interventions, specifically promoting flavonoid-rich diets, are a promising complementary strategy to pollution reduction for cardiovascular health.
- Public health initiatives should highlight the cardiovascular benefits of flavonoids.
- Further research is needed on the direct interplay between flavonoid intake and air pollution exposure.
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