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Safflower Yellow Injection Alleviates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative and Endoplasmic

Wulin Liang1, Mingqian Zhang1, Jiahui Gao1

  • 1School of Chinese Materia, Beijing University of Chinese Medicine, Beijing 102488, China.

Pharmaceuticals (Basel, Switzerland)
|August 29, 2024
PubMed
Summary

Safflower yellow injection (SYI) protects against heart damage from ischemia/reperfusion (I/R) injury. It reduces apoptosis, oxidative stress, and endoplasmic reticulum stress, offering new therapeutic insights.

Keywords:
apoptosisendoplasmic reticulum stressmyocardial ischemia/reperfusion injuryoxidative stresssafflower yellow injection

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Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Cell Biology

Background:

  • Safflower yellow injection (SYI) is a traditional Chinese medicine used for angina.
  • Its protective effects against myocardial ischemia/reperfusion (I/R) injury and underlying mechanisms are not well understood.

Purpose of the Study:

  • To investigate the protective effects of SYI on myocardial I/R injury.
  • To explore the mechanisms by which SYI exerts its protective effects.

Main Methods:

  • Myocardial I/R injury model in rats and oxygen-glucose deprivation/reoxygenation (OGD/R) in H9c2 cells.
  • Assessment of myocardial injury, apoptosis, oxidative stress (SOD, MDA, ROS), and endoplasmic reticulum (ER) stress markers (ATF6, GRP78, caspase-12, CHOP).

Main Results:

  • SYI significantly reduced infarct size and pathological damage in rat hearts.
  • SYI suppressed cardiomyocyte apoptosis, inhibited oxidative stress, and attenuated ER stress markers in vitro and in vivo.
  • SYI treatment increased SOD activity and decreased MDA and ROS levels.

Conclusions:

  • SYI demonstrates significant protective effects against myocardial I/R injury.
  • SYI ameliorates injury by reducing apoptosis, oxidative damage, and endoplasmic reticulum stress.
  • These findings provide new mechanistic insights into the therapeutic potential of SYI for myocardial I/R injury.