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Cytomegalovirus in Ulcerative Colitis: An Unwanted "Guest"
Danusia Onisor1,2, Olga Brusnic1,2, Simona Mocan3
1Department of Internal Medicine VII, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540139 Targu Mures, Romania.
Cytomegalovirus (CMV) reactivation can mimic ulcerative colitis (UC) flares. Vigilance for CMV is crucial in inflammatory bowel disease (IBD) management, especially before intensive treatments.
Area of Science:
- Gastroenterology
- Virology
- Immunology
Background:
- The role of cytomegalovirus (CMV) in ulcerative colitis (UC) flares remains unclear.
- CMV symptoms can overlap with UC, influenced by viral dynamics, host immunity, and IBD association.
Purpose of the Study:
- To clarify CMV's role in UC by detailing its clinical, endoscopic, and histopathological features.
- To review existing literature on CMV in IBD.
Main Methods:
- Clinical data analysis
- Endoscopic evaluation
- Histopathological examination
- Literature review
Main Results:
- Diverse presentations of CMV-related lesions identified.
- Key clinical, endoscopic, and histopathological markers established.
- Literature synthesis on CMV-IBD interactions.
Conclusions:
- Early detection of CMV reactivation is vital in IBD patients.
- Consider CMV in UC flares, particularly before escalating therapy.
- Integrated clinical, endoscopic, and histopathological assessment aids diagnosis.
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