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Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
209
Development of Human Microbiota01:30

Development of Human Microbiota

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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
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Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

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The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
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Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

98
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
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Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

233
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
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Gut-Brain Axis01:22

Gut-Brain Axis

222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
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Related Experiment Video

Updated: May 5, 2026

A Bacterial Oral Feeding Assay with Antibiotic-Treated Mosquitoes
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Mosquito Gut Microbiota: A Review.

Hongmei Liu1,2,3, Jianhai Yin1,3, Xiaodan Huang2

  • 1Key Laboratory of Parasite and Vector Biology, National Health Commission of People's Republic of China, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai 200025, China.

Pathogens (Basel, Switzerland)
|August 29, 2024
PubMed
Summary

Mosquito gut microbes influence insecticide resistance by degrading chemicals or altering host gene expression. Understanding these interactions is key to developing new strategies against resistant mosquitoes.

Keywords:
environmentgut microbiotainsecticide resistancemosquito

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Area of Science:

  • * Entomology
  • * Microbiology
  • * Vector Biology

Background:

  • * Mosquitoes transmit significant human diseases.
  • * Widespread insecticide use has driven mosquito resistance.
  • * Gut microbiota impacts mosquito physiology, disease transmission, and insecticide resistance.

Purpose of the Study:

  • * To review the role and mechanisms of mosquito gut microbiota in insecticide resistance.
  • * To synthesize current knowledge on microbiota-insecticide interactions.
  • * To identify knowledge gaps and future research directions.

Main Methods:

  • * Comprehensive literature search of major scientific databases (PubMed, MEDLINE, SciELO, Web of Science, Chinese Science Citation Database).
  • * Keywords included 'microbiota' and 'mosquitoes' (or specific species/genera).
  • * Review focused on microbiota's influence on mosquito growth, survival, reproduction, disease transmission, and insecticide resistance.

Main Results:

  • * Mosquito gut microbiota is diverse, dynamic, and varies by mosquito species, developmental stage, season, and environment.
  • * Microbiota composition significantly affects mosquito development, survival, and reproduction.
  • * Insecticide exposure alters microbial communities, with microbiota potentially enhancing resistance by degrading insecticides or modifying host detoxification pathways.

Conclusions:

  • * Mosquito gut microbiota plays a crucial role in insecticide resistance.
  • * Complex interactions exist between mosquito hosts, their microbiota, and insecticide exposure.
  • * Further research using multi-omics approaches is needed to elucidate these relationships and develop novel control strategies.