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Wrinkle Reduction Using Tetrapeptide-68 Contained in an O/W Formulation: A Randomized Double-Blind Placebo-Controlled
Sung-Gyu Lee1, Sang-Moon Kang2, Hyun Kang1
1Department of Medical Laboratory Science, College of Health Science, Dankook University, Cheonan-si 31116, Republic of Korea.
Pharmaceutics
|August 29, 2024
Summary
Tetrapeptide-68, a peptide derived from Loricrin, effectively reduces periorbital wrinkles in women aged 30-65. This anti-aging peptide shows promising results with no adverse reactions, enhancing skin texture and moisture.
Area of Science:
- Dermatology and Cosmetic Science
- Biochemistry of Peptides
- Skin Aging Research
Background:
- Peptides are increasingly utilized in anti-aging skincare due to their safety and efficacy.
- Tetrapeptide-68 is derived from Loricrin, a key structural protein in the skin.
- Periorbital wrinkles are a common concern addressed by cosmetic interventions.
Purpose of the Study:
- To evaluate the anti-wrinkle efficacy of Tetrapeptide-68 in a cosmetic formulation.
- To assess the effects of Tetrapeptide-68 on skin physiological parameters.
- To determine the safety and usability of Tetrapeptide-68 for periorbital wrinkles.
Main Methods:
- A 12-week, double-blind, randomized controlled trial involving 25 female participants (aged 30-65).
- Application of an oil-in-water (O/W) formulation containing Tetrapeptide-68 (100 ppm) around the eyes.
- Assessment of skin physiological parameters and wrinkle reduction using 3D imaging and roughness analysis at multiple time points.
Main Results:
- Significant improvements in wrinkle reduction were observed with Tetrapeptide-68 cream.
- Quantifiable enhancements in skin roughness parameters and 3D imaging analysis confirmed efficacy.
- Participants reported improved skin texture and hydration, with no adverse events.
Conclusions:
- Tetrapeptide-68 cream demonstrates significant anti-wrinkle effects on periorbital wrinkles.
- The peptide is safe and well-tolerated, showing potential as an effective anti-aging skincare ingredient.
- Further research is warranted to explore long-term benefits and mechanisms of action.
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