Drug Loading in Chitosan-Based Nanoparticles.

Area of Science:

• Biomaterials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Chitosan nanoparticles (CSNPs) are biodegradable, biocompatible, and low-toxicity drug delivery vehicles.
• Encapsulating drugs in nanoparticles (NPs) enhances bioavailability, minimizes side effects, and enables controlled release and targeted delivery.
• Low drug loading capacity is a significant challenge for current nanoparticle systems.

Purpose of the Study:

• To review recent advancements in developing CSNPs with high drug loading capacity.
• To summarize synthesis strategies for creating effective CSNP-based drug delivery systems.
• To provide guidelines for future CSNP development.

Main Methods:

• Literature review of recent research on CSNP synthesis and drug delivery applications.
• Analysis of various CSNP systems, materials, and drugs.
• Examination of synthesis methods, drug loading, encapsulation efficiency, release profiles, and stability.

Main Results:

• CSNPs demonstrate potential for targeted and controlled drug release.
• Various synthesis strategies exist for improving drug loading in CSNPs.
• Factors influencing drug loading efficiency have been identified.

Conclusions:

• CSNPs are promising for advanced drug delivery, but optimizing drug loading remains crucial.
• Further research into synthesis strategies can enhance CSNP efficacy.
• This review offers insights for developing next-generation CSNP drug delivery systems.