Sensing with Molecularly Imprinted Membranes on Two-Dimensional Solid-Supported Substrates.

Area of Science:

• Materials Science
• Analytical Chemistry
• Biomedical Engineering

Background:

• Molecularly imprinted membranes (MIMs) have been researched since 1990 for integrating target molecules into membranes.
• MIMs are crucial for developing advanced sensing applications.

Purpose of the Study:

• To provide a comprehensive overview of MIM development, preparation, and characterization.
• To explore the principles and diverse applications of MIMs in emerging technologies.
• To highlight advancements and challenges in MIM-based biosensors for point-of-care applications.

Main Methods:

• Review of developmental history and methodologies for MIM preparation and characterization on 2D solid-supported substrates.
• Exploration of MIM principles and applications in electrochemistry, SERS, SPR, and QCM.
• Analysis of ion-sensitive field-effect transistor (ISFET) biosensors utilizing MIMs.

Main Results:

• MIMs have evolved significantly since 1990, with diverse preparation and characterization techniques established.
• MIMs demonstrate broad applicability in electrochemical, SERS, SPR, and QCM sensing platforms.
• MIMs are integral to ISFET biosensors, showing promise for point-of-care diagnostics.

Conclusions:

• MIM technology has matured, offering versatile platforms for sophisticated sensing applications.
• Continued innovation in MIMs is expected to drive progress in point-of-care diagnostics and other biochemical sensing fields.
• This review provides insights into current advancements and future directions for MIM-driven sensing technologies.