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Neurological Complications Of Covid-19: Unraveling The Pathophysiological Underpinnings And Therapeutic Implications.

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Neurological Complications Of Covid-19: Unraveling The Pathophysiological Underpinnings And Therapeutic Implications.

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Neurological Complications of COVID-19: Unraveling the Pathophysiological Underpinnings and Therapeutic Implications.

Ashutosh Vashisht¹, Vishakha Vashisht¹, Harmanpreet Singh¹

¹Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

|August 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Coronavirus disease (COVID-19) significantly impacts neurological health, causing complications like anosmia, stroke, and encephalopathy. Understanding these neurobiological mechanisms is vital for effective treatment and long-term management of neuro-COVID.

Keywords:

COVID-19 NeuroCOVID SARS-CoV-2 neurological complications neurological manifestations

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Area of Science:

Neurology
Infectious Diseases
Neuroscience

Background:

Coronavirus disease (COVID-19), caused by SARS-CoV-2, presents diverse clinical symptoms beyond respiratory issues.
Neurological complications, including anosmia, seizures, stroke, and encephalopathy, are significant concerns in COVID-19 patients.
Increased mortality rates are observed in intensive care unit (ICU) patients with neurological challenges.

Purpose of the Study:

To review the neurological sequelae associated with SARS-CoV-2 infection.
To explore the neurobiological mechanisms underlying COVID-19's neurological manifestations.
To survey current therapeutic strategies and identify future research directions for neuro-COVID.

Main Methods:

Literature review of epidemiological, clinical, and diagnostic data on COVID-19 and neurological health.

Analysis of potential SARS-CoV-2 neuroinvasion routes.

Examination of pathophysiological underpinnings of neurological symptoms.

Main Results:

COVID-19 is linked to a wide spectrum of neurological complications, affecting patients across different severity levels.
The virus's interaction with the nervous system involves complex neurobiological pathways.
Neurological abnormalities in ICU patients correlate with poorer outcomes.

Conclusions:

A comprehensive understanding of COVID-19's neurological impact requires integrating diverse data.
Targeted therapeutic interventions and long-term management strategies are needed for neuro-COVID.
Further research into neurobiological mechanisms and therapeutic modalities is essential.