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Re-Emergence of DENV-3 in French Guiana: Retrospective Analysis of Cases That Circulated in the French Territories of the Americas from the 2000s to the 2023-2024 Outbreak

Re-Emergence of DENV-3 in French Guiana: Retrospective Analysis of Cases That Circulated in the French Territories of the Americas from the 2000s to the 2023-2024 Outbreak

Alisé Lagrave ¹, Antoine Enfissi ¹, Sourakhata Tirera ¹, Magalie Pierre Demar ², Jean Jaonasoa ², Jean-François Carod ³, Tsiriniaina Ramavoson ³, Tiphanie Succo ⁴, Luisiane Carvalho ⁴, Sophie Devos ⁴, Frédérique Dorleans ⁵, Lucie Leon ⁵, Alain Berlioz-Arthaud ⁶, Didier Musso ⁶, Anne Lavergne ¹, Dominique Rousset ¹

Alisé Lagrave ¹, Antoine Enfissi ¹, Sourakhata Tirera ¹

¹Arbovirus National Reference Center, Virology Unit, Institut Pasteur de la Guyane, Cayenne 97300, French Guiana.
²Laboratoire Centre Hospitalier de Cayenne, Cayenne 97300, French Guiana.
³Department of Biology, West French Guiana Hospital Center, Saint-Laurent-du-Maroni 97320, French Guiana.
⁴Santé Publique France, Cellule Guyane, Cayenne 97300, French Guiana.
⁵Santé Publique France, Cellule Antilles, French Caribbean Islands.
⁶Laboratoires Eurofins Guyane, French Guiana.

⁰Arbovirus National Reference Center, Virology Unit, Institut Pasteur de la Guyane, Cayenne 97300, French Guiana.

Viruses +

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August 29, 2024

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August 29, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

Dengue virus 3 (DENV-3) genotype III (GIII) strains, originating from Asia, caused recent epidemics in French Guiana and Martinique. Genomic surveillance is crucial for tracking DENV evolution and introductions.

Area Of Science

* Virology and Molecular Epidemiology
* Public Health and Infectious Diseases

Background

* French Guiana faced an unprecedented dengue epidemic in 2023-2024, with Dengue virus 3 (DENV-3) not seen epidemically since 2005.
* Understanding the genetic lineage and origin of circulating DENV-3 strains is critical for effective epidemic control.

Purpose Of The Study

* To retrospectively analyze DENV-3 strains circulating in the French Territories of the Americas (FTA) from the 2000s to the recent epidemic.
* To identify the origins and evolutionary patterns of DENV-3 strains contributing to recent outbreaks.

Main Methods

* Selection and sequencing of DENV-3 samples from the National Reference Center for Arboviruses in French Guiana (NRCA-FG).
* Utilized next-generation sequencing (NGS) with Oxford Nanopore Technologies (ONT).
* Performed phylogenetic analysis on 97 FTA DENV-3 sequences.

Main Results

* All 97 analyzed FTA sequences belonged to DENV-3 genotype III (GIII).
* From the 2000s to 2013, the GIII American-I lineage drove regional circulation via local extinctions and re-introductions.
* Multiple introductions of Asian-origin lineages were identified as the source for the 2019-2021 Martinique and 2023-2024 French Guiana epidemics.

Conclusions

* Genomic surveillance is essential for identifying circulating DENV genotypes and monitoring strain evolution.
* Understanding importation events is key to preventing and managing future dengue epidemics in the FTA.

Keywords:

DENV monitoring DENV-3 NGS molecular epidemiology re-emergence

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