Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.4K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K
CRISPR and crRNAs02:53

CRISPR and crRNAs

16.9K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
16.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tools to Quantify and Characterize the Persistent Reservoir in People with HIV-1: Focus on Non-B Subtypes.

Viruses·2026
Same author

Five dominant amino acid substitution signatures shape tumour immunity.

Molecular systems biology·2026
Same author

Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection.

mBio·2024
Same author

When less is more - a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping.

Journal of cell science·2024
Same author

Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy.

Frontiers in immunology·2024
Same author

The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication.

Viruses·2024

Related Experiment Video

Updated: Jun 14, 2025

Identification of Post-translational Modifications of Plant Protein Complexes
10:07

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

23.9K

Role of PQBP1 in Pathogen Recognition-Impact on Innate Immunity.

Lukas Wiench1, Domenico Rizzo1, Zora Sinay1

  • 1Host-Pathogen Interactions, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany.

Viruses
|August 29, 2024
PubMed
Summary

Polyglutamine-binding protein 1 (PQBP1) is crucial for innate immunity and links to neurodevelopmental disorders. This review explores PQBP1

Keywords:
PQBP1Renpenning syndrome spectruminnate immunityneurodegeneration

More Related Videos

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
08:04

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

6.9K
Bacterial Leaf Infiltration Assay for Fine Characterization of Plant Defense Responses using the Arabidopsis thaliana-Pseudomonas syringae Pathosystem
11:50

Bacterial Leaf Infiltration Assay for Fine Characterization of Plant Defense Responses using the Arabidopsis thaliana-Pseudomonas syringae Pathosystem

Published on: October 1, 2015

21.8K

Related Experiment Videos

Last Updated: Jun 14, 2025

Identification of Post-translational Modifications of Plant Protein Complexes
10:07

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

23.9K
Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
08:04

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

6.9K
Bacterial Leaf Infiltration Assay for Fine Characterization of Plant Defense Responses using the Arabidopsis thaliana-Pseudomonas syringae Pathosystem
11:50

Bacterial Leaf Infiltration Assay for Fine Characterization of Plant Defense Responses using the Arabidopsis thaliana-Pseudomonas syringae Pathosystem

Published on: October 1, 2015

21.8K

Area of Science:

  • Molecular Biology
  • Immunology
  • Neuroscience

Background:

  • The intrinsically disordered polyglutamine-binding protein 1 (PQBP1) is implicated in transcription, splicing, translation, and innate immunity.
  • PQBP1 mutations cause Renpenning syndrome spectrum disorders, characterized by impaired innate immune responses, notably against HIV-1.
  • PQBP1 plays a role in sensing viral pathogens and activating immune responses within the central nervous system.

Purpose of the Study:

  • To systematically review the structure, cellular functions, and interactome of PQBP1.
  • To elucidate the implications of PQBP1 in innate immune responses against various pathogens.
  • To explore the role of PQBP1 in neurodegenerative disorders, including tauopathies.

Main Methods:

  • Systematic literature review of existing data on PQBP1.
  • Analysis of PQBP1's structure and protein-protein interactions.
  • Examination of PQBP1's involvement in cellular processes and immune signaling pathways.

Main Results:

  • PQBP1 initiates the recognition of HIV-1 reverse-transcribed DNA, crucial for type 1 interferon response.
  • PQBP1 interacts with avian reovirus (ARV) and Kaposi's sarcoma-associated herpesvirus (KSHV), suggesting a broad role in antiviral immunity.
  • PQBP1 mediates microglia activation in tauopathies, indicating its significance in neuroinflammation.

Conclusions:

  • PQBP1's versatile functions, driven by its disordered nature and broad binding capabilities, are critical for cellular regulation and innate immunity.
  • Dysregulation of PQBP1 is linked to neurodevelopmental disorders and neurodegenerative conditions.
  • Further research into PQBP1's interactome and functional mechanisms can offer insights into therapeutic strategies for immune and neurological diseases.