Parent-mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a
Rachael Bedford1,2, Jonathan Green3,4, Teodora Gliga5
1Department of Psychology, University of Bath, Bath, UK.
Insights
The Intervention with the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting (iBASIS-VIPP) intervention reduced infant social attention dwell time. This eye-tracking finding suggests cognitive markers may be sensitive to early autism interventions.
Area of Science:
- Developmental Psychology
- Clinical Psychology
- Neuroscience
Background:
- Cognitive markers may offer greater sensitivity to intervention effects than behavioral measures.
- Early intervention is crucial for infants with elevated likelihood for autism (EL).
- Parenting interventions aim to enhance parental responsiveness to infant cues.
Purpose of the Study:
- To evaluate the impact of the iBASIS-VIPP intervention on infant social attention using eye-tracking.
- To assess changes in gaze following behavior as a cognitive marker in EL infants.
Main Methods:
- A randomized controlled trial (RCT) involving 54 EL infants (ages 9-15 months).
- Intervention group received iBASIS-VIPP; control group received no intervention.
- Eye-tracking measured dwell time to referred objects in a gaze following task at 15 months.
Main Results:
- The iBASIS-VIPP intervention was associated with significantly reduced dwell time to the referent of another's gaze (p=0.03).
- This eye-tracking finding was considered alongside previous non-significant trends in language scores.
Conclusions:
- The iBASIS-VIPP intervention demonstrated an effect on an eye-tracking measure of social attention in EL infants.
- Cognitive measures, such as eye-tracking, are valuable for assessing intervention effects in early autism research.
- Future trials should integrate cognitive and behavioral measures to explore intervention mechanisms.
Abstract:
Cognitive markers may in theory be more sensitive to the effects of intervention than overt behavioral measures. The current study tests the impact of the Intervention with the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting (iBASIS-VIPP) on an eye-tracking measure of social attention: dwell time to the referred object in a gaze following task. The original two-site, two-arm, assessor-blinded randomized controlled trial (RCT) of this intervention to increase parental awareness, and responsiveness to their infant, was run with infants who have an elevated familial likelihood for autism (EL). Fifty-four EL infants (28 iBASIS-VIPP intervention, 26 no intervention) were enrolled, and the intervention took place between 9 months (baseline) and 15 months (endpoint), with gaze following behavior measured at 15 months. Secondary intention to treat (ITT) analysis showed that the intervention was associated with significantly reduced dwell time to the referent of another person's gaze (β = -0.32, SE = 0.14, p = 0.03) at 15-month treatment endpoint. Given the established link between gaze following and language, the results are considered in the context of a previously reported, non-significant and transient trend toward lower language scores at the treatment endpoint (Green et al. (2015) The Lancet Psychiatry, 2(2), 133-140). Future intervention trials should aim to include experimental cognitive measures, alongside behavioral measures, to investigate mechanisms associated with intervention effects.
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