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Updated: Jun 14, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Acid-Promoted Self-Photocatalyzed Regioselective Oxidation: A Novel Strategy for Accessing Quinoxaline-2,3-diones
Shengjie Song1, Xiaoqing Peng1, Binjie Zhou2
1College of Pharmaceutical Sciences, Zhejiang University of Technology, No. 18 Chaowang Road, Hangzhou, Zhejiang, 310014, China.
Abstract:
Disclosed here is an efficient approach for the preparation of quinoxaline-2,3-diones using air (O2) as a green oxidant via acid-promoted self-photocatalyzed regioselective oxidation of quinoxalin-2(1H)-ones at C-3 position. This protocol presents a novel synthetic route for the preparation of quinoxaline-2,3-dione derivatives, featuring mild reaction conditions, simple operation, and a wide range of substrates, without the need for external photocatalysts, metal reagents, and strong oxidants.
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