Correlation of S100A4 and S100A14 Expression With Clinico-Pathological Features and Tumor Location in Colorectal Cancer Patients.

Area of Science:

• Oncology
• Molecular Biology
• Cancer Research

Background:

• Colorectal cancer (CRC) is a significant global health burden.
• S100 proteins are implicated in CRC progression, influencing tumor growth, metastasis, and inflammation.
• Specific S100 proteins may serve as prognostic biomarkers and therapeutic targets in CRC.

Purpose of the Study:

• To analyze clinical and pathological characteristics of CRC patients.
• To investigate the expression patterns of S100A4 and S100A14 proteins in CRC.
• To correlate S100A4 and S100A14 expression with tumor location and clinico-pathological features.

Main Methods:

• Cross-sectional study of 98 CRC patients.
• Collection of clinical data (age, gender, symptoms) and pathological data (TNM stage, invasion, grade).
• Immunohistochemical assessment of S100A4 and S100A14 protein expression.
• Statistical analysis to evaluate correlations.

Main Results:

• S100A4 expression was significantly higher in advanced CRC stages and associated with vascular, perineural, and lymph node invasion, and metastasis.
• Low S100A14 expression was observed in advanced stages and linked to increased vascular, lymph node invasion, and metastasis.
• No correlation was found between S100 protein expression and tumor location.

Conclusions:

• S100A4 and S100A14 expression levels are significantly correlated with key clinico-pathological features in CRC.
• High S100A4 expression indicates tumor aggressiveness and metastatic potential.
• Low S100A14 expression is associated with advanced CRC stages and poorer prognosis, suggesting their utility as biomarkers.