Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Anatomy of the Gastrointestinal System01:26

Anatomy of the Gastrointestinal System

The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
Here's a detailed walkthrough of this complex system:
Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated Spatial and Bulk Untargeted Metabolomics Characterize Location- and Histology-Associated Metabolic Heterogeneity in Colorectal Cancer.

Journal of proteome research·2026
Same author

Raman mapping as a quantitative tool for the visual analysis of Chinese mineral medicine.

Analytical methods : advancing methods and applications·2026
Same author

[Study on <i>In Vitro</i> Chromosome Aberration Test for Nanomaterials and Medical Devices Containing Nanomaterials].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation·2026
Same author

Predictive efficacy of PASP combined with NT-proBNP for outcomes in pregnant women with severe cardiovascular disease: a single-centre retrospective observational study.

BMC pregnancy and childbirth·2026
Same author

Efficacy of visualized reamer foraminoplasty in transforaminal endoscopic lumbar discectomy: a retrospective controlled study.

Frontiers in surgery·2026
Same author

Exercise Volume and Coronary Artery Calcification: A Systematic Review.

CJC open·2026

Related Experiment Video

Updated: Jun 28, 2026

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.2K

Technological advances and challenges in constructing complex gut organoid systems.

Longjin Zheng1,2, Yang Zhan1,2, Chenxuan Wang1,2

  • 1State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China.

Frontiers in Cell and Developmental Biology
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Gut organoids, derived from stem cells, offer a advanced model for studying the human gut, improving disease research and drug discovery. These biomimetic systems overcome limitations of traditional models, paving the way for personalized medicine.

Keywords:
3D bioprintingco-culture systemsgut organoidmicrofluidicsorgan-on-a-chip

More Related Videos

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

13.5K
Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
07:10

Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies

Published on: February 9, 2024

3.1K

Related Experiment Videos

Last Updated: Jun 28, 2026

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
05:27

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

4.2K
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

13.5K
Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
07:10

Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies

Published on: February 9, 2024

3.1K

Area of Science:

  • Biomedical Engineering
  • Gastroenterology
  • Stem Cell Biology

Background:

  • Organoid technology has advanced biomedical research, with gut organoids mimicking human intestine structure and function.
  • Gut organoids, derived from stem cells, surpass 2D cultures in modeling cell interactions and tissue dynamics.
  • These models are crucial for understanding intestinal physiology, disease, and therapeutic strategies.

Purpose of the Study:

  • To review technological advancements in creating sophisticated, biomimetic gut organoid systems.
  • To highlight engineering approaches for integrating immune and neural components into organoids.
  • To explore advanced fabrication techniques for improved tissue architecture replication.

Main Methods:

  • Utilizing stem cell-derived gut organoids.
  • Employing innovative engineering for cell type integration (immune, neural).
  • Applying advanced fabrication techniques like 3D bioprinting and microfluidics.

Main Results:

  • Development of gut organoids that better replicate the human gut's complexity.
  • Successful integration of diverse cell types to model gut microenvironment.
  • Enhanced biomimetic systems for studying gut physiology and disease.

Conclusions:

  • Gut organoids represent a significant advancement for personalized medicine and drug discovery.
  • These models minimize reliance on animal testing, promoting ethical research.
  • Future refinements will enhance scalability and accessibility for broader scientific and clinical applications.