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Updated: Jun 14, 2025
An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain
Published on: December 11, 2010
Research progress of migrasomes: from genesis to formation, physiology to pathology
Hua Tang1, Zhe Huang2,3,4, Ming Wang2,3,4
1Department of Neurosurgery, The People's Hospital of Jianyang City, Chengdu, China.
Abstract:
Migrasomes are recently identified organelles that form at the ends or forks of retraction fibers (RFs) behind migrating cells and are expelled from the cell through cell migration. Migrasomes contain signaling molecules which are captured by surrounding cells along with migrasomes or released into the extracellular environment following the rupture of the migrasomes. Finally, through the action of these signaling molecules, migrasomes facilitate the entire process of information conveyance. In addition, migrasomes also serves as a "scavenger" by removing damaged mitochondria from the cell to ensure cellular viability. Thus, migrasomes play a pivotal role in the integration of temporal, spatial, specific chemical information and the clearance of cellular harmful substances, critical for grasping migrasomes' functions. This review delves into the latest advancements in migrasomes research, covering aspects such as migrasomes' discovery, distribution, structure and characteristics, genesis and regulation mechanisms, and their correlation with diseases. Additionally, we scrutinize the present investigational findings on migrasomes within the cancer domain, examining their potential impact on cancer and prospective research avenues.
Insights
Migrasomes are novel organelles that transfer signals between cells and clear damaged mitochondria, crucial for cellular communication and health. This review explores their functions, formation, and role in diseases like cancer.
Area of Science:
- Cell Biology
- Organelle Biology
- Extracellular Vesicles
Background:
- Migrasomes are newly discovered organelles formed during cell migration.
- They are expelled from cells and contain signaling molecules and damaged mitochondria.
- Migrasomes play roles in intercellular communication and cellular housekeeping.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in migrasome research.
- To discuss the discovery, characteristics, formation, and regulation of migrasomes.
- To examine the involvement of migrasomes in disease, particularly cancer.
Main Methods:
- Literature review of recent studies on migrasomes.
- Analysis of findings on migrasome structure, function, and biogenesis.
- Investigation of migrasomes' role in cancer biology.
Main Results:
- Migrasomes facilitate intercellular signaling by transferring molecular cargo.
- They act as cellular 'scavengers,' removing damaged mitochondria to maintain cell viability.
- Migrasomes are implicated in various biological processes and diseases, including cancer.
Conclusions:
- Migrasomes are critical organelles involved in information transfer and cellular waste removal.
- Understanding migrasomes offers insights into fundamental biological processes and disease mechanisms.
- Further research into migrasomes, especially in oncology, holds significant therapeutic potential.
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