Related Experiment Video
Updated: Jun 14, 2025

Postoperative Ileus Murine Model
Published on: July 12, 2024
Immune-related intestinal pseudo-obstruction caused by immune checkpoint inhibitors: case report
Yimeng Qian1,2, Zheng Zhi3, Jing Ai1,4
1Department of Oncology, Hebei General Hospital, Shijiazhuang, China.
Abstract:
Intestinal obstruction, a rare manifestation of immunotherapy-related gastrointestinal adverse events, can be severe and even life-threatening with intestinal perforation. We present a 64-year-old man with HCC and currently under the therapy with Pembrolizumab, who was admitted in our hospital with abdominal distension. Radiologic findings were consistent with small bowel ileus. After conservative treatment, the patient underwent colonoscopy where no cause of ileus was discovered. The patient received high-dose prednisone due to the side effects of immune checkpoint inhibitor therapy. This resulted in a gradual improvement of symptoms.
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