Sleep-disordered breathing increases mortality in patients with diabetes
Teodora Vichova1,2, Marek Petras3, Petr Waldauf4
1Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Summary
Patients with diabetes and sleep-disordered breathing face higher mortality risks. Lower average oxygen saturation predicts death, while specific breathing disruptions increase mortality in treated diabetic patients.
Area of Science:
- Sleep Medicine
- Endocrinology
- Cardiovascular Disease Research
Background:
- Sleep-disordered breathing (SDB) and diabetes mellitus (DM) frequently coexist.
- Limited data exists on SDB's impact on mortality within the diabetic population.
Purpose of the Study:
- To investigate the association between SDB variables and mortality in patients with DM.
- To assess the influence of DM presence on SDB-related mortality outcomes.
Main Methods:
- Analysis of data from the Sleep Heart Health Study (5,780 participants, including 453 with DM).
- Utilized polysomnography and mortality data in a prospective observational design.
- Employed survival analysis and proportional hazard regression models to determine adjusted hazard ratios (aHRs).
Main Results:
- In diabetic patients, higher average oxygen saturation (>91.4%) correlated with reduced all-cause (aHR 0.52) and cardiovascular mortality (aHR 0.44).
- Severe SDB (Apnea-Hypopnea Index >31 or Oxygen Desaturation Index >13.3) increased all-cause mortality in treated diabetic patients (aHR 1.58 for both).
- Sleep efficiency and REM sleep duration did not impact mortality in diabetic patients, unlike in non-diabetic individuals.
Conclusions:
- Moderate to severe SDB is linked to increased all-cause mortality in treated diabetic patients.
- Reduced average oxygen saturation is a predictor of both all-cause and cardiovascular mortality in individuals with diabetes.
Keywords:
cardiovascular diseasediabetes mellitusmortalityoxygen saturationsleep-disordered breathingMore Related Videos
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